myosin heavy chains การใช้

• Myosin-11 is a smooth muscle myosin belonging to the myosin heavy chain family.
• Some mutations could have more harmful potential compared to others ( ? myosin heavy chain ).
• MiR-208 functions in cardiomyocytes regulating the production of the myosin heavy chain during development.
• In patients with congenital atrial septal defect carrying a missense mutation alpha myosin heavy chain is disrupted.
• Mutations of a heart muscle protein, ?-myosin heavy chain ( MYH6 ) are associated with atrial septal defects.
• Advancement to dilated cardiomyopathy may be more rapid in patients with TNNT2 mutations than in those with myosin heavy chain mutations.
• Some of his other research examined the relationship between neuregulin and expression of myosin heavy chain and transcription factors in human muscle.
• Once this complex is formed, these two proteins can regulate the alpha-myosin heavy chain ( ?-MHC ) gene expression.
• This recruitment leads to the repression of the MLC2v ( Myosin Light Chain 2 v ) and ?MHC ( ?-myosin heavy chain ) promoter.
• Of the hundreds of pathogenic mutations that give rise to HCM, R403Q mutations in myosin heavy chain genes are present in over half of them.
• For example, using the Cre recombinase with the alpha-myosin heavy chain promoter causes the floxed gene to be inactivated in the heart alone.
• These findings impact the available knowledge regarding muscle spindle fiber formation, myosin heavy chains development, and the feasibility of mimicking muscle development processes in vitro.
• Using the ?-myosin heavy chain gene promoter in the cardiac muscle cells, also called cardiomyocytes, Mydicar is able to direct the gene expression only to the heart muscle.
• In individuals without a family history, the most common cause of the disease is a'de novo'mutation of the gene that produces the ?-myosin heavy chain.
• These are predominantly single-point missense mutations in the genes for the beta-myosin heavy chain ( MHC ), myosin-binding protein C, cardiac troponinT, or tropomyosin.
• The majority of familial HCM cases have been linked to a mutation in beta-myosin heavy chains converting a single amino acid from an arginine to a glutamine at the 403rd position.
• This may occur through serotonylation modifying proteins integral to the contractility and the cytoskeleton such as alpha-actin, beta-actin, gamma-actin, myosin heavy chain and filamin A
• Approximately 45 % of these mutations occur in the ? myosin heavy chain gene on chromosome 14 q11.2-3, while approximately 35 % involve the cardiac myosin binding protein C gene.
• Phosphorylation of cardiac myosin heavy chains ( see MYH7B ) and light chains ( see MYL2 ) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes.
• Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP . Myosin is a hexameric protein composed of a pair of myosin heavy chains ( MYH ) and two pairs of nonidentical light chains.